Wrexsoul starts off using an attack called Fury, which makes it disappear and possess a character's body. To get it to reappear, the character whom it possessed must be petrified or KOed. The Soul Savers can be defeated easily, but they revive every time. As such, the party members must defeat and revive each other until Wrexsoul reappears when can be attacked until it uses Fury again. This pattern repeats until the player kills Wrexsoul.
Wrexsoul's special attack, Doom Strike, is only used when sketched or Wrexsoul is confused.
It is possible to defeat the Soul Savers permanently and never have to fight Wrexsoul. Due to their final attack the Soul Savers revive when killed, but if the player kills them using Banish, this stalls their final attack and they don't revived — when both Soul Savers are killed by Banish the battle ends and Wrexsoul is considered defeated. However, winning this way forsakes the Guard Bracelet Wrexsoul drops. If Wrexsoul is present when both Soul Savers are killed by Banish, the battle will end when he next uses Fury.
Another way to easily beat him is to have a character equipped with Icebrand and a Gauntlet to attack him.
WrexSoul's Japanese name, アレクソウルArekusouru, looks like "Alex Soul," and may be associated with the esperAlexander which can be obtained immediately after defeating WrexSoul. The name "WrexSoul" was originally selected by 1994 Super NES version translator Ted Woolsey.