Prima Donna may refer to:
- The weapon from Lightning Returns: Final Fantasy XIII.
- The clan from Final Fantasy Tactics A2: Grimoire of the Rift.
prima donna, meaning "first woman (ie. "lady") in Italian, was the leading singer in a opera company, the person to whom the prime roles would be given. Traditionally, these women were often regarded as egotistical, unreasonable and irritable, with a rather high opinion of themselves not shared by others.A