Nightshade may refer to:
- An enemy from Final Fantasy VI.
- The Job of Illua from Final Fantasy Tactics A2: Grimoire of the Rift.
Nightshade, refers to the family of flowering plants, famous for some of the species' deadly poison. The most famous specimen is probably the Deadly Nightshade, or Belladonna. The leaves, seeds, and roots are deadly poison, but the extract was historically used as a cosmetic.