Nephilim Flute may refer to:
- The weapon from Dissidia Final Fantasy.
- The weapon from Dissidia 012 Final Fantasy.
- The weapon from Final Fantasy Record Keeper.
The Nephilim were offspring of the "sons of God" and the "daughters of men" before the Deluge according to Genesis 6:4; they were said to later inhabit Canaan at the time of the Israelite conquest of Canaan according to Numbers 13:33.