Melusine may refer to:
- The boss from Final Fantasy V.
- The enemy from Final Fantasy X.
- The enemy from Final Fantasy XI.
- The boss from Final Fantasy XIV.
- The enemy from Bravely Default.
- The summon from Final Fantasy Legends: Toki no Suishō.
Melusine is a female spirit that inhabits or watches over water. Similar to a siren or mermaid, Melusine generally possesses one or more serpent or fish tails and a woman's torso and head. Sometimes she also has wings. Several noble houses took great pride in claiming to be descended from Melusine, notably the Plantagenet Dynasty of England.In European mythology,