Grendel may refer to:
- The enemy from Final Fantasy VIII.
- The enemy from Final Fantasy X.
- The possible choice for a name from Final Fantasy XIII-2.
- The boss from Lightning Returns: Final Fantasy XIII.
Grendel is one of the three antagonists in the epic poem Beowulf. He terrorizes the mead hall, Heorot, until Beowulf comes to slay him. Said to be the decedent of Cain, he is usually depicted as a foul monster or beast.