Destrudo may refer to:
- The enemy ability from Final Fantasy XIII.
- The enemy ability from Final Fantasy Record Keeper.
- The ability from Mobius Final Fantasy.
Destrudo is a term introduced by Italian psychoanalyst Edoardo Weiss in 1935 to denote the energy of the death instinct, on the analogy of libido — and thus to cover the energy of the destructive impulse in Freudian psychology.