It is a very dangerous enemy, and uses various Death attacks, such as the Death spell, Blaster, and Lv. 5 Death, which it casts at the beginning of every battle. Their special attack Mind Stop inflicts Stop, and when followed by Blaster, it's guaranteed to KO the afflicted party member. Like most machines, it is weak to Lightning and Water, so Thundaga spells are most effective against it.
The Death Machine can be fought in Dragon's Neck Coliseum by betting a Regal Gown. Their Death attacks can instantly end the battle, but an easy way to win is to equip the character with a Reflect Ring; with it simple battle script, the Death Machine will likely destroy itself as soon as the first turn.