Anathema may refer to:
- The enemy ability from Final Fantasy XIII.
- The weapon from Final Fantasy XIV.
- The weapon from Dissidia Final Fantasy Opera Omnia.
Anathema, in common usage, is something or someone that is detested or shunned. In its other main usage, it is a formal excommunication. The latter meaning, its ecclesiastical sense, is based on New Testament usage. In the Old Testament, anathema referred either to something (living or inanimate) that was consecrated or something denounced as evil or accursed and set aside for sacrificial offering.